What is Pulsed Field Ablation ?

Unlike cryoablation or radiofrequency ablation, pulsed field ablation does not use a thermal energy delivery form to perform irreversible ablation. Instead, locally fast, pulsatile electrical high-voltage fields are generated, which lead to the formation of irreversible pores in the cell membrane (electroporation) and thus to cell death. By precisely adjusting the electroporation, only myocytes are destroyed; adjacent structures such as the esophagus, the phrenic nerve or coronary arteries are spared.

 

In addition, the “tissue architecture” of the ablated tissue remains largely intact, so that, for example, there is hardly any physiological volume reduction of the scar tissue due to contraction of the collagen fibers contained in the scar. By positioning the PFA catheter in the pulmonary veins, pulmonary vein isolation can be performed and the risk of feared complications such as pulmonary vein stenosis or esophageal injury can be prevented.

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