{"id":604,"date":"2021-02-24T12:14:51","date_gmt":"2021-02-24T12:14:51","guid":{"rendered":"http:\/\/beat-af.com\/?page_id=604"},"modified":"2022-03-16T11:09:52","modified_gmt":"2022-03-16T11:09:52","slug":"about-the-trial","status":"publish","type":"page","link":"https:\/\/beat-af.com\/?page_id=604","title":{"rendered":"ABOUT THE TRIAL"},"content":{"rendered":"\r\n\t<section class=\"section\" id=\"section_1915003912\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\r\n\r\n<div class=\"text-center\"><div class=\"is-divider divider clearfix\" style=\"max-width:213px;height:4px;background-color:rgb(212, 12, 12);\"><\/div><\/div>\r\n\r\n<h1 style=\"text-align:center; font-size:60px\">ABOUT THE TRIAL<\/span><\/h1>\r\n\t<div id=\"gap-503395423\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style scope=\"scope\">\n\n#gap-503395423 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\r\n\r\n<div class=\"row row-large align-middle\" style=\"max-width:1300px\" id=\"row-550040555\">\r\n\r\n\n\t<div class=\"col medium-12 small-12 large-7\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\r\n\r\n\n  <div class=\"banner has-hover\" id=\"banner-1952875170\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                                    \n                    <\/div>\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \r\n\r\n\r\n        <\/div>\n      <\/div>\n\n            \n<style scope=\"scope\">\n\n#banner-1952875170 {\n  padding-top: 300px;\n  background-color: rgb(255, 255, 255);\n}\n#banner-1952875170 .bg.bg-loaded {\n  background-image: url(https:\/\/beat-af.com\/wp-content\/uploads\/2021\/10\/iStock-1027141710-1232x800.jpg);\n}\n\n\n@media (min-width:550px) {\n\n  #banner-1952875170 {\n    padding-top: 500px;\n  }\n\n}\n<\/style>\n  <\/div>\n\n\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\n\t<div class=\"col medium-10 small-12 large-5\"  >\n\t\t<div class=\"col-inner\" style=\"padding:0px 0px 0px 30px;\" >\n\t\t\t\n\t\t\t\r\n\r\n\t<div id=\"gap-1033799382\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style scope=\"scope\">\n\n#gap-1033799382 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\r\n\r\n<h2>THE BEAT-AF PROJECT<\/h2>\r\n<div class=\"is-divider divider clearfix\" style=\"max-width:100px;height:4px;background-color:rgb(212, 12, 12);\"><\/div>\r\n\r\n<p>The BEAT-AF, Ground-BrEAking Electroporation-based inTervention for Atrial Fibrillation treatment is an action funded by the <a href=\"https:\/\/ec.europa.eu\/info\/funding-tenders\/opportunities\/portal\/screen\/home\"><span style=\"color: #ffff00;\">European Commission<\/span><\/a> for 60 months and started on March, 1<sup>st<\/sup>, 2021. It is part of the HADEA agency <span style=\"color: #ffff00;\">(<a style=\"color: #ffff00;\" href=\"https:\/\/hadea.ec.europa.eu\/index_en\">European Health and Digital Executive Agency<\/a>)<\/span>.<\/p>\r\n<p>The BEAT-AF consortium regroup 9 partners all over Europe (France, Germany, Belgium, Austria, Czechia) presented in the \u201cmeet the centers\u201d. The coordinator is <a href=\"https:\/\/www.ihu-liryc.fr\/fr\/professeur-pierre-jais\/\"><span style=\"color: #ffff00;\">Pr Pierre Ja\u00efs<\/span><\/a> from Bordeaux University.<\/p>\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\r\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\r\n<div class=\"row row-large align-middle\" style=\"max-width:1300px\" id=\"row-1834717409\">\r\n\r\n\n\t<div class=\"col medium-10 small-12 large-5\"  >\n\t\t<div class=\"col-inner\" style=\"padding:0px 0px 0px 30px;\" >\n\t\t\t\n\t\t\t\r\n\r\n\t<div id=\"gap-585891547\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style scope=\"scope\">\n\n#gap-585891547 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\r\n\r\n<h2>ATRIAL FIBRILLATION<\/h2>\r\n<div class=\"is-divider divider clearfix\" style=\"max-width:100px;height:4px;background-color:rgb(212, 12, 12);\"><\/div>\r\n\r\n<p>Atrial fibrillation (AF), the most common arrhythmia, accounts for 1\/3rd of Cardiovascular expenses, with over 10 millions affected in Europe. In addition to significant impact on quality of life, AF exposes patients to stroke, heart failure, dementia and death. AF is the most commonly ablated arrhythmia. The Pulmonary Vein Isolation (PVI) is the cornerstone of AF ablation, preventing recurrences, especially in patients with paroxysmal AF. Catheter ablation of AF uses either radio-frequency (RF) or cryothermal (cryo) energy. Common to these thermal energy sources is their reliance on time-dependent conductive heating\/cooling and the fact that these modalities ablate all tissue types indiscriminately. The ablation procedure remains long, requires skills and expertise, and has a limited success rate, mostly because of non-durable lesions after PVI implying frequent redo procedures. And these energies are associated with rare but severe complications due to their thermal nature.<\/p>\r\n<p>\u00a0<\/p>\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\n\t<div class=\"col medium-12 small-12 large-7\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\r\n\r\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_1160698959\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-800x800.jpeg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-800x800.jpeg 800w, https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-400x400.jpeg 400w, https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-280x280.jpeg 280w, https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-768x768.jpeg 768w, https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-1536x1536.jpeg 1536w, https:\/\/beat-af.com\/wp-content\/uploads\/2021\/09\/9XHipJ7A-2048x2048.jpeg 2048w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style scope=\"scope\">\n\n#image_1160698959 {\n  width: 100%;\n}\n<\/style>\n\t<\/div>\n\t\r\n\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\r\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\r\n<div class=\"row\"  id=\"row-1637945781\">\r\n\r\n\n\t<div class=\"col small-12 large-12\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\r\n\r\n<div class=\"text-center\"><div class=\"is-divider divider clearfix\" style=\"max-width:226px;height:6px;background-color:rgb(31, 57, 137);\"><\/div><\/div>\r\n\r\n<h2 class=\"uppercase\" style=\"text-align: Center;\">THE BEAT AF TRIAL and its goals<\/h2>\r\n<p>The goal of BEAT AF is to disrupt AF ablation by achieving durable PVI with permanent, coalescent and transmural ablation lesions using Pulsed Electric Field (PEF) energy. PEF is non-thermal and creates nanoscale pores in cell membranes. Cardiac cells are highly sensitive to PEF unlike phrenic and oesophageal cells.<\/p>\r\n<p>BEAT AF aims to demonstrate that PEF ablation is faster, more effective and safer (tissue selectivity) than RF or cryo ablation. For this purpose, two distinct randomized clinical trials will be conducted:<\/p>\r\n<p>1) to provide first comparative evidence of the superiority of PEF over RF on the rate of 1-year recurrence for paroxysmal AF, and<\/p>\r\n<p>2) to provide first evidence of potential efficacy of PEF on the rate of 1-year clinical recurrence for persistent AF.<\/p>\r\n<p>The BEAT AF consortium gathers 9 European renowned clinical centres (France, Czech Republic, Germany, Austria, Belgium) to set the ground for large trials and contribute to decrease the huge burden of AF in Europe.<\/p>\r\n<p>UPDATES:<\/p>\r\n<p><strong>September 2021<\/strong>: We are working on obtaining the authorizations to conduct the trials in the different countries by submitting the protocol to the local ethic committees, under the new European law on trials on medical devices.<\/p>\r\n<p>FACT SHEET BEAT AF:<\/p>\r\n<p><a href=\"https:\/\/cordis.europa.eu\/project\/id\/945125\">https:\/\/cordis.europa.eu\/project\/id\/945125<\/a><\/p>\r\n<p>\u00a0<\/p>\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\r\n<\/div>\r\n\r\n\t\t<\/div>\n\n\t\t\n<style scope=\"scope\">\n\n#section_1915003912 {\n  padding-top: 50px;\n  padding-bottom: 50px;\n  background-color: #1f3989;\n}\n\n\n@media (min-width:550px) {\n\n  #section_1915003912 {\n    padding-top: 0px;\n    padding-bottom: 0px;\n  }\n\n}\n<\/style>\n\t<\/section>\n\t\r\n\t<section class=\"section\" id=\"section_81435615\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\r\n\r\n\t<div id=\"gap-631537728\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style scope=\"scope\">\n\n#gap-631537728 {\n  padding-top: 60px;\n}\n<\/style>\n\t<\/div>\n\t\r\n\r\n<div class=\"row align-center\"  id=\"row-1032325082\">\r\n\r\n\n\t<div class=\"col medium-10 small-12 large-10\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\r\n\r\n<div class=\"row row-large\"  id=\"row-889008582\">\r\n\r\n\r\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\r\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\r\n\r\n\t\t<\/div>\n\n\t\t\n<style scope=\"scope\">\n\n#section_81435615 {\n  padding-top: 0px;\n  padding-bottom: 0px;\n  background-color: #1f3989;\n}\n<\/style>\n\t<\/section>\n\t\r\n\n  <div class=\"banner has-hover\" id=\"banner-973743735\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                        <div class=\"overlay\"><\/div>            \n                    <\/div>\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \r\n\r\n   <div id=\"text-box-813268332\" class=\"text-box banner-layer x50 md-x50 lg-x50 y50 md-y50 lg-y50 res-text\">\n                                <div class=\"text dark\">\n              \n              <div class=\"text-inner text-center\">\n                  \r\n\r\n<h1 style=\"text-transform:uppercase;\">Our Video<\/h1>\r\n\r\n              <\/div>\n           <\/div>\n                            \n<style scope=\"scope\">\n\n#text-box-813268332 {\n  width: 88%;\n}\n#text-box-813268332 .text {\n  font-size: 100%;\n}\n<\/style>\n    <\/div>\n \r\n\r\n        <\/div>\n      <\/div>\n\n            \n<style scope=\"scope\">\n\n#banner-973743735 {\n  padding-top: 82px;\n  background-color: #1f3989;\n}\n#banner-973743735 .overlay {\n  background-color: rgba(0, 0, 0, 0.17);\n}\n<\/style>\n  <\/div>\n\n\r\n<div class=\"row\" style=\"max-width:999px\" id=\"row-844532010\">\r\n\r\n\n\t<div class=\"col small-12 large-12\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\r\n\r\n<div class=\"epyt-video-wrapper\"><iframe loading=\"lazy\"  id=\"_ytid_93221\"  width=\"1020\" height=\"573\"  data-origwidth=\"1020\" data-origheight=\"573\"  data-relstop=\"1\" src=\"https:\/\/www.youtube.com\/embed\/1VdoCAAzod4?enablejsapi=1&autoplay=0&cc_load_policy=0&cc_lang_pref=&iv_load_policy=1&loop=0&modestbranding=1&rel=0&fs=1&playsinline=0&autohide=2&theme=dark&color=red&controls=1&\" class=\"__youtube_prefs__  no-lazyload\" title=\"YouTube player\"  allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen data-no-lazy=\"1\" data-skipgform_ajax_framebjll=\"\"><\/iframe><\/div>\r\n\r\n\t\t<\/div>\n\t<\/div>\n\n\t\r\n\r\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\r\n\t<section class=\"section dark\" id=\"section_743553032\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n\t<div id=\"gap-335420067\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style scope=\"scope\">\n\n#gap-335420067 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\n\n<div class=\"row\"  id=\"row-1975922680\">\n\n\n\t<div class=\"col medium-12 small-12 large-4\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_1626340212\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"417\" height=\"191\" src=\"https:\/\/beat-af.com\/wp-content\/uploads\/2021\/02\/Untitled-design-e1614040997588.png\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style scope=\"scope\">\n\n#image_1626340212 {\n  width: 60%;\n}\n\n\n@media (min-width:550px) {\n\n  #image_1626340212 {\n    width: 30%;\n  }\n\n}\n\n\n@media (min-width:850px) {\n\n  #image_1626340212 {\n    width: 60%;\n  }\n\n}\n<\/style>\n\t<\/div>\n\t\n\n\t<div id=\"gap-1456834893\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style scope=\"scope\">\n\n#gap-1456834893 {\n  padding-top: 10px;\n}\n<\/style>\n\t<\/div>\n\t\n\n<p>IHU Liryc<br \/>\nCampus Xavier Arnozan<br \/>\nAvenue du Haut L\u00e9v\u00e8que, 33600 Pessac-Bordeaux-France<\/p>\n<a href=\"http:\/\/+335%203538%201938\" target=\"_self\" class=\"button white is-link is-small\"  >\n  <i class=\"icon-phone\" ><\/i>  <span>Call us<\/span>\n  <\/a>\n\n\n<a href=\"http:\/\/beat-af.management@ihu-liryc.fr\" target=\"_self\" class=\"button white is-link is-small\"  >\n  <i class=\"icon-envelop\" ><\/i>  <span>E-mail<\/span>\n  <\/a>\n\n\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\t<div class=\"col medium-12 small-12 large-8\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<div class=\"row row-small\"  id=\"row-908821000\">\n\n\n\t<div class=\"col hide-for-medium medium-8 small-12 large-8\"  >\n\t\t<div class=\"col-inner\" style=\"margin:-21px 0px 0px -74px;\" >\n\t\t\t\n\t\t\t\n\n<ul class=\"sidebar-wrapper ul-reset\"><\/ul>\n\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\t<div class=\"col show-for-small medium-8 small-12 large-8\"  >\n\t\t<div class=\"col-inner\" style=\"margin:0px 0px 0px -17px;\" >\n\t\t\t\n\t\t\t\n\n<ul class=\"sidebar-wrapper ul-reset\"><\/ul>\n\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\t<div class=\"col show-for-medium hide-for-small medium-8 small-12 large-8\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<ul class=\"sidebar-wrapper ul-reset\"><\/ul>\n\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\t<div class=\"col medium-4 small-12 large-4\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<h4>Menu<\/h4>\n<ul>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">Home<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">About the trial<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">Publications<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">Meet the participant<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">What is AF<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">What is PFA<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">Contact Us<\/a><\/span><\/li>\n<li class=\"bullet-arrow\"><span style=\"font-size: 90%;\"><a href=\"#\">Members Login<\/a><\/span><\/li>\n<\/ul>\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\n<div class=\"row\"  id=\"row-1488956443\">\n\n\n\t<div class=\"col small-12 large-12\"  >\n\t\t<div class=\"col-inner\" style=\"margin:-30px 0px -30px 0px;\" >\n\t\t\t\n\t\t\t\n\n<div class=\"is-divider divider clearfix\" style=\"max-width:100%;height:2px;background-color:rgb(255, 255, 255);\"><\/div>\n\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\n<style scope=\"scope\">\n\n<\/style>\n<\/div>\n<div class=\"row hide-for-small\"  id=\"row-1720145667\">\n\n\n\t<div class=\"col medium-4 small-12 large-4\"  >\n\t\t<div class=\"col-inner text-left\"  >\n\t\t\t\n\t\t\t\n\n<p>&nbsp;<\/p>\n<p>\u00a9 2026 Beat AF<\/p>\n\n\t\t<\/div>\n\t<\/div>\n\n\t\n\n\t<div class=\"col medium-4 small-12 large-4\"  >\n\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<div class=\"social-icons follow-icons full-width text-center\" ><a href=\"#\" target=\"_blank\" data-label=\"Facebook\"  rel=\"noopener noreferrer nofollow\" class=\"icon plain facebook tooltip\" title=\"Follow on Facebook\"><i class=\"icon-facebook\" ><\/i><\/a><a href=\"#\" target=\"_blank\" rel=\"noopener noreferrer nofollow\" data-label=\"Instagram\" class=\"icon plain  instagram tooltip\" title=\"Follow on Instagram\"><i class=\"icon-instagram\" ><\/i><\/a><a href=\"#\" target=\"_blank\"  data-label=\"Twitter\"  rel=\"noopener 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